If you happen across a spilled litter box mess, take the time to get a paper towel to clean up large chunks. Don't just vacuum it up.
If you do decide to vacuum it up, make sure that your vacuum bag is almost full. Because you WILL be emptying that vacuum bag the next time you need to vacuum. When the litter box smell spreads through the room every time you turn it on, you WILL throw out that vacuum bag (no matter how empty it is) and start over.
It pays to think about these things before you vacuum something up. Unfortunately, I usually learn from hindsight.
Rejoicing in Family,